COMPOSITION
Ceftiofur (hydrochloride) 50 mg
Excipient q.s. 1 ml
PROPERTIES
It contains ceftiofur hydrochloride which is a broad spectrum cephalosporin active against Gram
positive and Gram negative bacteria, including B-lactamase producing strains. Like all cephalosporins,
it is bactericidal. Its mechanism of action is by inhibition of the cell wall.
INDICATIONS
Indicated in the treatment and control of infectious processes caused by germs sensitive to
ceftiofur.
Cattle, sheep and goats: for treatment of respiratory syndrome in cattle (shipping fever, pneumonia)
associated with Pasteurella haemolytica, Pasteurella multocida and Haemophilus somnus.
Treatment of interdigital necrobacillosis associated with Fusobacterium necrophorum and B.
melaninogenicus. Treatment of bacterial pneumonias associated with Actinobacillus pleuropneumoniae,
Pasteurella multocida, Salmonella choleraesuis and Streptococcus suis.
Pigs: Treatment of bacterial respiratory diseases. Pneumonia, pleuropneumonia, Pasteurella
multocida, haemorrhagic septicemia, salmonellosis, meningitis streptococcus type 2, for the
treatment of neonatal colibacillosis.
Horses: Treatment of respiratory disease caused by germs sensitive to ceftiofur, in adult horses.
TARGET SPECIES
Cattle, sheep, goats, pigs and horses.
DOSAGE AND ROUTE OF ADMINISTRATION
Cattle, sheep and goats: The dosage is 1-2 ml of Nobac.cf per 50 Kg of body weight (1-2 mg of
ceftiofur per Kg b.w.), by deep intramuscular or subcutaneous injection each 24 hours.
Pigs: Administer 1 to 3 ml of Nobac.cf / 50 Kg of body weight (equivalent to 1-3 mg of Ceftiofur/Kg
of b.w.) by deep intramuscular injection every 24 hours for 3 - 5 days.
Horses: One dose of 2,2 mg of Ceftiofur / Kg b.w., by deep intramuscular injection, every 24 hours,
according to discretion of the veterinarian.
CONTRAINDICATIONS
Do not use in animals with a history of hypersensitivity to ceftiofur or other B-lactam antibiotics.
SIDE EFFECTS
Occasionally a transient local swelling may occur at the site of intramuscular injection.
OVERDOSAGE
Ceftiofur has a wide margin of safety. The therapeutic index in cattle is 50 times the recommended
dose, therefore, poisoning due to overdose is very unlikely, especially when used at the recommended
doses.
WITHDRAWAL TIME
Meat: 2 days. Milk: 0 days.
INTERACTIONS
It is recommended to avoid the administration of aminoglycosides at the same time.
STORAGE CONDITIONS AND RECOMMENDATIONS
Keep in a cool dry place, protected from light. Do not store above 30°C. Keep out of sight and
reach of children and domestic animals. Sold under veterinary prescription only.
PRESENTATIONS
Vials of 50 ml and 100 ml.