NAM PHUC THINH TRADING CO., LTD

DOXYPREX

Doxycycline hyclate (INN)

Composition: Doxycyclin (hyclate) 100 g, excipient q.s 1 kg

Pharmaceutical form: Premix for medicated feeding stuff

Pharmacodynamic properties: Doxycycline  is a bacteriostatic antibacterial agent that acts by interfering on the bacterial protein synthesis of the sensitive species. Doxycycline is a semi-synthetic tetracycline derived from oxytetracycline that acts on the 30S ribosome bacterial subunit in a reversible union, by blocking the binding of aminoacyl-tRNA (transference RNA) to the mRNA/ribosome complex, avoiding the addition of new amino acids to the growing peptide chain and interfering therefore on the protein synthesis. It is active against: Mycoplasma hyopneumoniae, Pasteurella multocida, Bordetella bronchiseptica…

Advantages: Doxyprex is produced by BMP (Bi Modal Protection) molecular protection with the following effects:

• To avoid degradation of doxycycline and enhance homogeneity and stability of the premix
• Minimizes the losses of antibiotic activity: In the premix: guaranteed 3 years; during granulation of feed; during storage of feed.
• Minimum dust production: Lower health risks for workers; lower risk of dust explosions in the factory
• Palatability: pigs do not detect it. Doxycycline hyclate is bitter so adding up to 500 ppm make consumption normal.
• Reduce formation of electrostatic charges in contact with the walls of the mixing tubes and containers = less risk of cross-contaminations.
• Are mixed homogeneously with the feed    until a perfect granulation = homogeneous medication

Target species: Swine and poultry

Indications for use: Treatment and prevention of Porcine Respiratory Complex caused by: Pasteurella multocida, Bordetella bronchiseptica and Mycoplasma hyopneumoniae.

Posology and method of administration:

Provided the administration form and that the feed consumption depends on the clinical condition of the animal, in order to obtain a correct dosage, the concentration of the antimicrobial agent should be adjusted taking into account the daily feed intake.

The recommended dose is 250 mg of doxycycline per kg of feed )equivalent to 2.5 kg Doxyprex/ton of feed) constituting this medicated feed the only ration during 7 consecutive days.

Before granulation, flour should not reach a temperature higher than 550C.

ORAL ROUTE IN FEED

• Do not administer in animals with hypersensitivity to tetracyclinies. Do not administer to animals with hepatic damage. Do not use in pregnant animals and during lactation periods.

Undesirable effects (frequency and seriousness): Allergic reactions and photosensitivity may appears, as for all tetracyclines. Digestive alterations by intestinal dysbiosis may appear in very long-term treatments.

• (symptoms, emergency procedures, antidotes), if necessary: No symptoms of intolerance to the speciality have been detected in the studies conducted in which a medicated feed with 600 ppm was administered to the 20 – 30 kg animals during twice the recommended period.

Interaction with other medicaments and other forms of interaction: Absorption of doxycycline may be diminished with the presence of high quantities of calcium, iron, magnesium or aluminium in the diet. Do not administer together with antacids, kaolin and iron preparations.

Special precautions for use: In the presence of any infectious process it is recommended the bacteriological confirmation of the diagnostic and the performance of a sensitivity test of the bacteria responsible for the process. Administration in oxidized places should be avoided.

Withdrawal periods: Meat: 7 days

Storage conditions: Store below 300C.

Shelf-life: 3 years from the manufacturing date; 3 months from the first opening and medicated premix.

Presentations: Containers of 1 kg, 5 kg, 20 kg and 25 kg.

FOR VETERINARY USE ONLY

Keep out of the reach of children

Invesa

Industrial Veterinaria, S.A.

a LIVISTO company

Esmeralda, 19

08950 Esplugues de Llobregat

(Barcelona) Spain