NAM PHUC THINH TRADING CO., LTD

STIMIXIN LIQUIDO

Compositions:
1 g contains: Colistin sulphate 120 mg; Excipients: Benzyl alcohol other q.s. to 1 g

Pharmaceutical form: Oral solution for use in drinking water or liquid feed.

Target species: Milking calves, pigs, broilers, turkeys, laying hens and rabbits.

Indications:  Milking calves, pigs, broilers, turkeys, laying hens and rabbits: to treat bacterial enteritis caused by Gram-negative germs such as Bordetella, Enterobacter, Escherichia coli, Haemophilus, Klebsiella, Pasteurella multocida, Pseudomonas aeruginosa, Salmonella.

Contraindications:  Gastroenteric absorption of colistin sulphate is poor; however, avoid using the product in animals that display symptoms of kidney failure. Do not use in animals that are known to be hypersensitive to Colistin or to any one of the excipients.

Side effects: Oral administration in prolonged and/or excessive doses may in rare cases cause gastro-intestinal disorders (vomiting, nausea, and diarrhea). Parenteral administration may have neurotoxic repercussions. Avoid simultaneous administration with nephrotoxic and/or neurotoxic drugs. Should severe reactions occur or other reactions not mentioned on the label, please inform the veterinarian.

Dosage, route and method of administration: The product must be administered dissolved in drinking water and/or liquid feed, as per the indications of the prescribing Veterinarian, being careful not to exceed the authorised daily dosage in mg/Kg b.w. Milking calves, pigs, broilers, turkeys, laying hens and rabbits: from 4.2 to 5 g of product every 100 Kg of body weight equal to 5 – 6 mg/Kg b.w. of Colistin sulphate. To avoid underdosage, the body weight must be determined in the most accurate way.
The consumption of the medicated water depends on the clinical conditions of animals.
To obtain a correct dose, the concentration of the antimicrobial product must be calculated accordingly.
Administer only in liquid feed or drinking water. Do not mix in solid feed.
Treatment period: 3-15 days.

Withdrawal periods: Meat and offal: milking calves: 7 days; pigs: 7 days; broilers: 0 days; turkeys: 1 day, rabbits: 5 days.
Eggs: laying hens: 0 days

Special storage conditions: This veterinary medicinal product does not require any special storage temperature. Keep away from light. Keep out of the reach of children. Use within 15 days after frst opening.
Shelf-life: 12 months

Shelf-life after first opening of the container: 15 days
Shelf-life after dilution: 12 hours.

Special warnings:

Special warnings for each target species: The uptake of the medicated water could be reduced due to disease. For
animals with reduced intake of water, run the parenteral treatment, using a suitable injectable product, as instructed
by a veterinarian. The repeated or prolonged use should be avoided, improving management practices by cleaning and
disinfection.

Special precautions for use
Special precautions for use in animals: Use the veterinary product (colistin) in broilers as required by CE Regulation 1177/2006 of the European Commission and by national legislation that implements its contents. Due to variability (time, geographical) in susceptibility of bacteria for Colistin, bacteriological sampling and susceptibility testing are recommended. The misuse of the product may increase the prevalence of bacteria resistant to Colistin and may decrease the effectiveness of treatment with other antibiotics of the polymyxins, due to possible cross-resistance.
Special precautions to be taken by the person administering the medicinal product to animals: Use protective gear when handling the product, i.e. protective clothing, gloves and mask; do not inhale, avoid contact with skin and eyes. In the event of accidental contact, wash thoroughly with soap and water. If irritation persists, consult a doctor. Do not eat, drink or smoke when handling the product; wash your hands after use. Persons known to be hypersensitive to colistin or its excipients must avoid contact with the veterinary medical product.
Use during pregnancy and lactation: No negative effects on reproductive system are known. The antibiotic is not embryo-toxic, teratogenic and mutagenic.
Interactions with other veterinary medicinal products and other forms of interaction: It develops cross-resistance with Polymyxin B.
Overdose: There are no known symptoms from overdose. Do not exceed recommended doses.

Incompatibilities: Do not mix with other medicinal products

SPECIAL PRECAUTIONS TO TAKE WHEN DISPOSING OF UNUSED MEDICINAL OR WASTE PRODUCTS: All unused medicinal products or waste produced by the latter must be disposed of in accordance with local laws and handed over to the responsible waste collection centers for unused or expired medicinal products.

Presentations: bottles of 1 kg and 5 kg

FOR VETERINARY USE ONLY

Keep out of the reach of children

Industria Italiana Integratori TREI S.p.A

42010 Rio Saliceto (RE) Italy - Via Affarosa, 4